Praz-Delavallade has a longstanding relationship with both American and European artists whose practices span a variety of mediums. The gallery was founded 1995 in Paris with an inaugural exhibition that included work by Paul McCarthy, Mike Kelley, Richard Petitbon, Jim Shaw, and Benjamin Weisman. In 1997, Praz-Delavallade was part of a burgeoning art scene in the 13th arrondissement on the eastern side of Paris, along with Air de Paris, Almine Rech, Art: Concept, Jennifer Flay, and Emmanuel Perrotin.

In the fall of 2016, Praz-Delavallade opened a new outpost at 6150 Wilshire Boulevard—on the renowned thoroughfare in Miracle Mile right across from the Los Angeles County Museum of Art—in an effort to create a bridge between the two cities it calls home.